Ki Summary

Reaction Details

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Target

Cannabinoid receptor 1

Ligand

BDBM50029980

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1438383 (CHEMBL3383058)

36±n/a nM

Citation

Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allar�, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem57:8777-91 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 1

Name:

Cannabinoid receptor 1

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52868.96

Organism:

Homo sapiens (Human)

Description:

P21554

Residue:

472

Sequence:

MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL

BDBM50029980

n/a

Name

BDBM50029980

Synonyms:

CHEMBL3353438

Type

Small organic molecule

Emp. Form.

C22H30FN3O2

Mol. Mass.

387.4909

SMILES

CC1CCC(CC1)NC(=O)c1cc2cccnc2n(CCCCCCF)c1=O |(16.3,-12.78,;14.97,-13.55,;14.97,-15.09,;13.65,-15.86,;12.31,-15.09,;12.3,-13.56,;13.63,-12.78,;10.98,-15.87,;9.64,-15.11,;9.63,-13.57,;8.31,-15.89,;6.97,-15.13,;5.65,-15.9,;4.31,-15.13,;2.98,-15.91,;2.98,-17.45,;4.32,-18.22,;5.65,-17.44,;6.98,-18.21,;6.99,-19.75,;8.32,-20.52,;8.33,-22.06,;9.66,-22.82,;9.66,-24.36,;11,-25.13,;11,-26.67,;8.32,-17.43,;9.66,-18.2,)|

Structure