Ki Summary

Reaction Details

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Target

Cannabinoid receptor 1

Ligand

BDBM50030093

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1438383 (CHEMBL3383058)

>10000±n/a nM

Citation

Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allar�, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem57:8777-91 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 1

Name:

Cannabinoid receptor 1

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52868.96

Organism:

Homo sapiens (Human)

Description:

P21554

Residue:

472

Sequence:

MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL

BDBM50030093

n/a

Name

BDBM50030093

Synonyms:

CHEMBL3353429

Type

Small organic molecule

Emp. Form.

C22H31N3O3

Mol. Mass.

385.4998

SMILES

CC1CCC(CC1)NC(=O)c1cc2cccnc2n(CCCCCCO)c1=O |(10.21,-20.68,;8.88,-21.45,;8.88,-22.99,;7.56,-23.76,;6.22,-22.99,;6.21,-21.46,;7.54,-20.69,;4.89,-23.77,;3.55,-23.01,;3.54,-21.47,;2.22,-23.79,;.88,-23.03,;-.44,-23.8,;-1.78,-23.04,;-3.12,-23.81,;-3.11,-25.35,;-1.79,-26.12,;-.45,-25.34,;.89,-26.11,;.9,-27.65,;2.23,-28.42,;3.57,-27.64,;4.9,-28.41,;6.23,-27.64,;7.57,-28.41,;8.9,-27.63,;2.23,-25.34,;3.57,-26.1,)|

Structure