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TargetCannabinoid receptor 2
LigandBDBM50029974
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1438384
Ki 0.960000±n/a nM
Citation Lucchesi VHurst DPShore DMBertini SEhrmann BMAllarÓ MLawrence LLigresti AMinutolo FSaccomanni GSharir HMacchia MDi Marzo VAbood MEReggio PHManera C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 2
Name:Cannabinoid receptor 2
Synonyms:CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:39690.94
Organism:Homo sapiens (Human)
Description:P34972
Residue:360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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BDBM50029974
n/a
NameBDBM50029974
Synonyms:CHEMBL3353446
TypeSmall organic molecule
Emp. Form.C27H26FN3O2S
Mol. Mass.475.578
SMILESC[C@H]1CC[C@H](CC1)NC(=O)c1cc2cc(cnc2n(Cc2ccc(F)cc2)c1=O)-c1cccs1 |r,wD:4.7,1.0,(18.83,-4.26,;17.5,-5.03,;16.16,-4.27,;14.82,-5.04,;14.83,-6.57,;16.18,-7.35,;17.5,-6.57,;13.51,-7.35,;12.17,-6.59,;12.16,-5.05,;10.84,-7.37,;9.5,-6.61,;8.18,-7.38,;6.84,-6.62,;5.51,-7.39,;5.51,-8.93,;6.84,-9.7,;8.18,-8.93,;9.51,-9.69,;9.52,-11.23,;10.85,-12,;10.85,-13.54,;12.18,-14.3,;13.52,-13.53,;14.85,-14.29,;13.51,-11.98,;12.17,-11.22,;10.85,-8.92,;12.18,-9.68,;4.17,-6.62,;2.76,-7.25,;1.73,-6.1,;2.5,-4.76,;4.01,-5.08,)|
Structure
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