| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50030475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1434935 (CHEMBL3385872) |
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| EC50 | 0.210000±n/a nM |
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| Citation |  Gege, C; Schlüter, T; Hoffmann, T Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. Bioorg Med Chem Lett24:5265-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 48288.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11473 |
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| Residue: | 427 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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| BDBM50030475 |
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| n/a |
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| Name | BDBM50030475 |
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| Synonyms: | 7-Dehydrocholesterol | CHEBI:28940 | Cholecalciferol | Colecalciferol | Dihydrocholesterol | Vitamin D | Vitamin D 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H44O |
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| Mol. Mass. | 384.6377 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)C |r| |
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| Structure | 
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