| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 5B |
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| Ligand | BDBM50033887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1436465 (CHEMBL3390780) |
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| Kd | 42±n/a nM |
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| Citation |  Cumaraswamy, AA; Lewis, AM; Geletu, M; Todic, A; Diaz, DB; Cheng, XR; Brown, CE; Laister, RC; Muench, D; Kerman, K; Grimes, HL; Minden, MD; Gunning, PT Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein. ACS Med Chem Lett5:1202-1206 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 5B |
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| Name: | Signal transducer and activator of transcription 5B |
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| Synonyms: | STA5B_HUMAN | STAT5B | Signal transducer and activator of transcription 5B | Transcription factor STAT5b (STAT5b) |
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| Type: | Protein |
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| Mol. Mass.: | 89858.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 787 |
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| Sequence: | MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
WIPHAQS
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| BDBM50033887 |
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| n/a |
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| Name | BDBM50033887 |
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| Synonyms: | CHEMBL3358611 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H36ClF5N2O6S |
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| Mol. Mass. | 767.202 |
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| SMILES | CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C |
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| Structure | 
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