| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50034089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437207 (CHEMBL3382981) |
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| Ki | 0.970000±n/a nM |
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| Citation |  Lan, Y; Chen, Y; Cao, X; Zhang, J; Wang, J; Xu, X; Qiu, Y; Zhang, T; Liu, X; Liu, BF; Zhang, G Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem57:10404-23 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50034089 |
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| n/a |
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| Name | BDBM50034089 |
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| Synonyms: | CHEMBL3359238 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClF2N3O |
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| Mol. Mass. | 381.847 |
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| SMILES | Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(F)c(F)c1 |
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| Structure | 
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