| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
|---|
| Ligand | BDBM50036311 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1432010 (CHEMBL3388115) |
|---|
| IC50 | 4.6±n/a nM |
|---|
| Citation |  Playa, H; Lewis, TA; Ting, A; Suh, BC; Muņoz, B; Matuza, R; Passer, BJ; Schreiber, SL; Buolamwini, JK Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett24:5801-4 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Equilibrative nucleoside transporter 1 |
|---|
| Name: | Equilibrative nucleoside transporter 1 |
|---|
| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 50225.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 456 |
|---|
| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
|
|
|
|---|
| BDBM50036311 |
|---|
| n/a |
|---|
| Name | BDBM50036311 |
|---|
| Synonyms: | CHEMBL3353074 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H42N2O10 |
|---|
| Mol. Mass. | 590.6619 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)C(=O)OCCCN1CCCN(CCOC(=O)c2cc(OC)c(OC)c(OC)c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
