| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 2 |
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| Ligand | BDBM50017691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432011 (CHEMBL3388116) |
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| IC50 | 8800±n/a nM |
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| Citation |  Playa, H; Lewis, TA; Ting, A; Suh, BC; Muņoz, B; Matuza, R; Passer, BJ; Schreiber, SL; Buolamwini, JK Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett24:5801-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Equilibrative nucleoside transporter 2 |
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| Name: | Equilibrative nucleoside transporter 2 |
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| Synonyms: | Ent2 | Equilibrative NBMPR-insensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter | Equilibrative nucleoside transporter 2 | Nucleoside transporter, ei-type | S29A2_RAT | Slc29a2 | Solute carrier family 29 member 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50265.69 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_103616 |
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| Residue: | 456 |
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| Sequence: | MAHGNAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQGRLAGTNSSAETPSTNHTSP
TDTFNFNNWVTLLSQLPLLLFTLLNSFLYQCIPESVRILGSLLAILLLFALTAALVKVDL
SPGLFFSITMASVWFINSFCAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLTS
LASGVDPQTSALGYFITPCVGILLSIICYLSLPHLKFARYYLTKKPQAPVQELETKAELL
GADEKNGIPVSPQQAGPTLDLDPEKELELGLEEPQKPGKPSVFVVFRKIWLTALCLVLVF
TVTLSVFPAITAMVTTSSNSPGKWSQFFNPICCFLLFNVMDWLGRSLTSYFLWPDEDSQL
LPLLVCLRFLFVPLFMLCHVPQRARLPIIFWQDAYFITFMLLFAISNGYFVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
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| BDBM50017691 |
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| n/a |
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| Name | BDBM50017691 |
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| Synonyms: | CHEMBL126075 | dilazep |
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| Type | Small organic molecule |
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| Emp. Form. | C31H44N2O10 |
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| Mol. Mass. | 604.6885 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)OCCCN1CCCN(CCCOC(=O)c2cc(OC)c(OC)c(OC)c2)CC1 |
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| Structure | 
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