Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50037094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1435873 (CHEMBL3390734) |
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IC50 | 4320±n/a nM |
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Citation | Reddy, KI; Srihari, K; Renuka, J; Sree, KS; Chuppala, A; Jeankumar, VU; Sridevi, JP; Babu, KS; Yogeeswari, P; Sriram, D An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition. Bioorg Med Chem22:6552-63 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | GYRB_MYCSM | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 74505.25 |
Organism: | Mycobacterium smegmatis |
Description: | ChEMBL_107961 |
Residue: | 675 |
Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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BDBM50037094 |
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n/a |
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Name | BDBM50037094 |
Synonyms: | CHEMBL3355787 |
Type | Small organic molecule |
Emp. Form. | C23H25N3O4 |
Mol. Mass. | 407.4623 |
SMILES | CCOC(=O)c1cc2cc(ccc2o1)N1CCN(CC1)C(=O)NCc1ccccc1 |
Structure |
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