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TargetNonstructural protein NS3-4A
LigandBDBM50037498
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437305
Ki 220±n/a nM
Citation Lampa AAlogheli HEhrenberg AE┼kerblom ESvensson RArtursson PDanielson UHKarlÚn ASandstr÷m A Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles. Bioorg Med Chem 22:6595-615 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nonstructural protein NS3-4A
Name:Nonstructural protein NS3-4A
Synonyms:Nonstructural protein NS3-4A
Type:PROTEIN
Mol. Mass.:71633.49
Organism:Hepatitis C virus
Description:ChEMBL_109716
Residue:674
Sequence:
SPITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVFHGAG
SKTLAGPKGPITQMYTNVDQDLVGWMAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFVPVESMETTMR
SPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAGTDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIICDECHSTDSTTLGI
GTVLDQAETAGARLVVLATATPPGSTVPHPNIEEVALSTTGEIPFYGKAIPIETIKGGRH
LIFCHSKKKCDELAGKLSALGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDS
VIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRGIYRFVTPGERPSGM
FDSSVLCECYDAGCAWYELTPAETTRLRAYLNTPGLPVCQDHLEFWEGVFTGLTIDAHFL
SQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLRLKPTLHGPTPLLYRLGAVQNE
ITLTHPITKIMTCMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVP
DREVLYEFDEMEEC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50037498
n/a
NameBDBM50037498
Synonyms:CHEMBL3356703
TypeSmall organic molecule
Emp. Form.C37H39N5O7S
Mol. Mass.697.8
SMILESCC(C)(C)OC(=O)N[C@H](C(=O)Nc1ccccc1C(=O)NS(=O)(=O)CCCC=C)c1ccc(Oc2cc(C=C)nc(n2)-c2ccccc2)cc1 |r|
Structure
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