Reaction Details |
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Target | Biotin--protein ligase |
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Ligand | BDBM50039493 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1445407 (CHEMBL3379106) |
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IC50 | 39700±n/a nM |
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Citation | Sittiwong, W; Cordonier, EL; Zempleni, J; Dussault, PH ฿-Keto and฿-hydroxyphosphonate analogs of biotin-5'-AMP are inhibitors of holocarboxylase synthetase. Bioorg Med Chem Lett24:5568-71 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Biotin--protein ligase |
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Name: | Biotin--protein ligase |
Synonyms: | BPL1_HUMAN | Biotin apo-protein ligase | Biotin--[acetyl-CoA-carboxylase] ligase | Biotin--[methylcrotonoyl-CoA-carboxylase] ligase | Biotin--[methylmalonyl-CoA-carboxytransferase] ligase | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase | HCS | HLCS | Holocarboxylase synthetase |
Type: | PROTEIN |
Mol. Mass.: | 80745.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1475435 |
Residue: | 726 |
Sequence: | MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR
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BDBM50039493 |
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n/a |
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Name | BDBM50039493 |
Synonyms: | CHEMBL3357333 |
Type | Small organic molecule |
Emp. Form. | C21H33N8O8PS |
Mol. Mass. | 588.574 |
SMILES | [NH4+].[H][C@]12CS[C@@H](CCCCC(=O)CP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)[C@@]1([H])NC(=O)N2 |r| |
Structure |
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