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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50040799 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1444239 (CHEMBL3380178) | ||
| IC50 | 100±n/a nM | ||
| Citation |  Chaudhary, D; Robinson, S; Romero, DL Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem58:96-110 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM50040799 | |||
| n/a | |||
| Name | BDBM50040799 | ||
| Synonyms: | CHEMBL3353186 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H26N6 | ||
| Mol. Mass. | 350.4606 | ||
| SMILES | CN(C)[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2)nc2[nH]ccc12 |r,wU:3.2,wD:6.9,(56.02,-20.97,;57.35,-21.74,;57.35,-23.28,;58.69,-20.98,;58.69,-19.44,;60.02,-18.68,;61.36,-19.45,;61.36,-20.98,;60.02,-21.75,;62.69,-18.68,;62.69,-17.14,;61.36,-16.37,;61.36,-14.83,;60.03,-14.06,;58.69,-14.83,;57.36,-14.05,;56.03,-14.82,;56.03,-16.36,;57.37,-17.13,;58.7,-16.36,;62.69,-14.06,;64.02,-14.82,;65.49,-14.34,;66.41,-15.59,;65.49,-16.84,;64.02,-16.37,)| | ||
| Structure | 
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