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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50040800 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1444239 (CHEMBL3380178) | ||
| IC50 | 100±n/a nM | ||
| Citation |  Chaudhary, D; Robinson, S; Romero, DL Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem58:96-110 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM50040800 | |||
| n/a | |||
| Name | BDBM50040800 | ||
| Synonyms: | CHEMBL3353185 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C14H20FN5 | ||
| Mol. Mass. | 277.3405 | ||
| SMILES | CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2[nH]cc(F)c12 |r,wU:3.2,wD:6.9,(43.41,-21.28,;44.74,-22.06,;44.74,-23.59,;46.08,-21.29,;46.09,-19.75,;47.41,-18.99,;48.75,-19.76,;48.75,-21.3,;47.41,-22.06,;50.08,-18.99,;50.08,-17.45,;48.75,-16.68,;48.75,-15.14,;50.08,-14.37,;51.41,-15.13,;52.89,-14.65,;53.8,-15.9,;52.89,-17.15,;53.37,-18.61,;51.41,-16.68,)| | ||
| Structure | 
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