| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50042442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444284 (CHEMBL3380867) |
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| IC50 | 963±n/a nM |
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| Citation |  Kurata, H; Gentry, PR; Kokubo, M; Cho, HP; Bridges, TM; Niswender, CM; Byers, FW; Wood, MR; Daniels, JS; Conn, PJ; Lindsley, CW Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges. Bioorg Med Chem Lett25:690-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 60161.80 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 |
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| Residue: | 531 |
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| Sequence: | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQL
KTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL
LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPD
ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKK
REPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVT
TCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKY
FLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPN
LSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY
WLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50042442 |
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| n/a |
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| Name | BDBM50042442 |
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| Synonyms: | CHEMBL3353277 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F3N2O3 |
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| Mol. Mass. | 452.4252 |
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| SMILES | COc1ccc(cc1C)C12N(CCN1C(=O)c1ccccc21)C(=O)c1cc(F)c(F)c(F)c1 |
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| Structure | 
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