Reaction Details | |||
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Target | Serine/threonine-protein kinase Sgk1 | ||
Ligand | BDBM50043016 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1444808 (CHEMBL3379051) | ||
IC50 | 670±n/a nM | ||
Citation | Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett6:19-20 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Sgk1 | |||
Name: | Serine/threonine-protein kinase Sgk1 | ||
Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) | ||
Type: | Other Protein Type | ||
Mol. Mass.: | 48954.40 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. | ||
Residue: | 431 | ||
Sequence: |
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BDBM50043016 | |||
n/a | |||
Name | BDBM50043016 | ||
Synonyms: | CHEMBL3355026 | US9718825, Example 3 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H21ClFN5O4S | ||
Mol. Mass. | 517.96 | ||
SMILES | OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |(44.14,-2.28,;42.6,-2.28,;41.82,-3.61,;40.29,-3.61,;39.52,-2.26,;40.28,-.93,;41.83,-.94,;37.97,-2.27,;37.2,-3.6,;35.66,-3.61,;34.89,-4.94,;35.66,-6.28,;37.2,-6.27,;38.22,-7.42,;39.63,-6.81,;39.48,-5.28,;37.98,-4.95,;33.36,-4.93,;32.58,-6.27,;31.04,-6.26,;30.28,-4.92,;28.73,-4.91,;27.96,-6.24,;29.29,-7.02,;27.96,-7.78,;26.42,-6.25,;25.65,-4.92,;24.1,-4.92,;23.33,-3.59,;23.34,-6.25,;24.11,-7.58,;25.65,-7.58,;26.42,-8.92,;31.04,-3.59,;32.58,-3.59,)| | ||
Structure |