Reaction Details |
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Target | Maternal embryonic leucine zipper kinase |
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Ligand | BDBM50043369 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1444812 (CHEMBL3379055) |
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IC50 | 4200±n/a nM |
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Citation | Johnson, CN; Berdini, V; Beke, L; Bonnet, P; Brehmer, D; Coyle, JE; Day, PJ; Frederickson, M; Freyne, EJ; Gilissen, RA; Hamlett, CC; Howard, S; Meerpoel, L; McMenamin, R; Patel, S; Rees, DC; Sharff, A; Sommen, F; Wu, T; Linders, JT Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett6:25-30 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Maternal embryonic leucine zipper kinase |
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Name: | Maternal embryonic leucine zipper kinase |
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
Type: | Enzyme |
Mol. Mass.: | 74665.45 |
Organism: | Homo sapiens (Human) |
Description: | Q14680 |
Residue: | 651 |
Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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BDBM50043369 |
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n/a |
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Name | BDBM50043369 |
Synonyms: | CHEMBL3355055 |
Type | Small organic molecule |
Emp. Form. | C23H25N3O4 |
Mol. Mass. | 407.4623 |
SMILES | COc1cc(O)cc(Nc2ccc(C(=O)Nc3ccccc3)c(OCCCN)c2)c1 |
Structure |
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