| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
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| Ligand | BDBM50043932 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1445188 (CHEMBL3375440) |
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| IC50 | 46±n/a nM |
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| Citation |  Halland, N; Schmidt, F; Weiss, T; Saas, J; Li, Z; Czech, J; Dreyer, M; Hofmeister, A; Mertsch, K; Dietz, U; Strübing, C; Nazare, M Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett6:73-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk1 |
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| Name: | Serine/threonine-protein kinase Sgk1 |
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| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 48954.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
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| Residue: | 431 |
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| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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| BDBM50043932 |
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| n/a |
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| Name | BDBM50043932 |
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| Synonyms: | CHEMBL3356027 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N5O2S |
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| Mol. Mass. | 403.457 |
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| SMILES | Cc1ccc(cc1S(=O)(=O)Nc1ccc(cc1)-c1ccc2c(N)n[nH]c2c1)C#N |
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| Structure | 
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