| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily M member 8 |
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| Ligand | BDBM20284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452556 (CHEMBL3363423) |
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| IC50 | >50000±n/a nM |
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| Citation |  Terada, Y; Kitajima, M; Taguchi, F; Takayama, H; Horie, S; Watanabe, T Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives. J Nat Prod77:1831-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily M member 8 |
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| Name: | Transient receptor potential cation channel subfamily M member 8 |
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| Synonyms: | LTrpC-6 | Long transient receptor potential channel 6 | Ltrpc6 | TRPM8_MOUSE | Transient receptor potential p8 | Trp-p8 | Trpm8 | Trpp8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127713.99 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_107992 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRSRRNGTMGSTRTLYSSVSRSTDVSYSDSDLVNFIQANFKKRECVFFTRD
SKAMENICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRL
SCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRSCDDEGHFSAQY
IMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIP
IVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVR
FLPRTVSRLPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDR
SSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFKCCCKEKNMESNACCFRNEDNETLAWEGVMKENYLVKINTKANDNSEEMRH
RFRQLDSKLNDLKSLLKEIANNIK
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| BDBM20284 |
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| n/a |
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| Name | BDBM20284 |
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| Synonyms: | CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-2-benzazepine-2-carbothioamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21ClN2O2S |
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| Mol. Mass. | 376.9 |
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| SMILES | Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1 |
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| Structure | 
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