Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone deacetylase 1 | ||
| Ligand | BDBM50044639 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1450056 (CHEMBL3373318) | ||
| IC50 | 41±n/a nM | ||
| Citation |  Tashima, T; Murata, H; Kodama, H Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors. Bioorg Med Chem22:3720-31 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone deacetylase 1 | |||
| Name: | Histone deacetylase 1 | ||
| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55090.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13547 | ||
| Residue: | 482 | ||
| Sequence: |
| ||
| BDBM50044639 | |||
| n/a | |||
| Name | BDBM50044639 | ||
| Synonyms: | CHEMBL3309300 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H31N3O4 | ||
| Mol. Mass. | 401.4992 | ||
| SMILES | CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]1CC[C@H](CCC(=O)NO)CC1 |r,wU:17.18,20.22,(45.27,-32.85,;46.06,-34.2,;46.81,-32.85,;47.39,-34.97,;47.39,-36.51,;48.73,-37.28,;46.06,-37.28,;44.72,-36.51,;43.39,-37.28,;42.06,-36.51,;42.06,-34.97,;43.39,-34.2,;44.72,-34.97,;40.73,-34.2,;40.73,-32.66,;39.39,-34.97,;38.06,-34.2,;36.72,-34.97,;35.39,-34.2,;34.05,-34.96,;34.04,-36.5,;32.71,-37.27,;31.38,-36.49,;30.04,-37.26,;30.03,-38.8,;28.71,-36.48,;27.37,-37.24,;35.38,-37.28,;36.72,-36.51,)| | ||
| Structure | 
| ||