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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone deacetylase 3 | ||
| Ligand | BDBM50044636 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1450058 (CHEMBL3373320) | ||
| IC50 | 15±n/a nM | ||
| Citation |  Tashima, T; Murata, H; Kodama, H Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors. Bioorg Med Chem22:3720-31 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone deacetylase 3 | |||
| Name: | Histone deacetylase 3 | ||
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48829.55 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O15379 | ||
| Residue: | 428 | ||
| Sequence: |
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| BDBM50044636 | |||
| n/a | |||
| Name | BDBM50044636 | ||
| Synonyms: | CHEMBL3309297 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H29N3O4 | ||
| Mol. Mass. | 399.4834 | ||
| SMILES | CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@H]1CC[C@@H](CC1)\C=C\C(=O)NO |r,wU:17.18,wD:20.25,(21.24,-20.14,;22.02,-21.48,;22.78,-20.14,;23.36,-22.25,;23.36,-23.79,;24.69,-24.56,;22.02,-24.56,;20.69,-23.79,;19.36,-24.56,;18.02,-23.79,;18.02,-22.25,;19.36,-21.48,;20.69,-22.25,;16.7,-21.48,;16.7,-19.94,;15.36,-22.25,;14.02,-21.48,;12.69,-22.25,;12.69,-23.8,;11.35,-24.56,;10.01,-23.79,;10.02,-22.25,;11.35,-21.48,;8.67,-24.55,;7.34,-23.78,;6.01,-24.54,;6,-26.08,;4.68,-23.76,;3.34,-24.53,)| | ||
| Structure | 
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