| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM50045493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1447539 (CHEMBL3373146) |
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| Ki | 0.670000±n/a nM |
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| Citation |  Moritomo, A; Yamada, H; Watanabe, T; Itahana, H; Koga, Y; Akuzawa, S; Okada, M Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2. Bioorg Med Chem22:4323-37 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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| BDBM50045493 |
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| n/a |
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| Name | BDBM50045493 |
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| Synonyms: | CHEMBL3310116 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClN3O2 |
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| Mol. Mass. | 317.77 |
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| SMILES | Cl.[#6]-c1cccc2-c3ccc(cc3-[#6](-[#8])-c12)-[#6](=O)\[#7]=[#6](/[#7])-[#7] |
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| Structure | 
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