Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50024458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1449308 (CHEMBL3371454) |
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IC50 | >25000±n/a nM |
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Citation | Armstrong, MM; Diaz, G; Kenyon, V; Holman, TR Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorg Med Chem22:4293-7 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase |
Type: | Enzyme |
Mol. Mass.: | 75309.71 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | 15-LO enzyme was purified from phenylhydrazine treated rabbits. |
Residue: | 663 |
Sequence: | MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
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BDBM50024458 |
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n/a |
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Name | BDBM50024458 |
Synonyms: | 5-oxo-ETE | CHEMBL18028 | ETE-5-Oxo |
Type | Small organic molecule |
Emp. Form. | C20H30O3 |
Mol. Mass. | 318.4504 |
SMILES | CCCCC\C=C/C\C=C/CC=CC=CC(=O)CCCC(O)=O |w:13.12,11.10| |
Structure |
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