| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Ligand | BDBM50025735 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1450151 (CHEMBL3375138) |
|---|
| Ki | 87±n/a nM |
|---|
| Citation |  Armstrong, MM; Diaz, G; Kenyon, V; Holman, TR Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorg Med Chem22:4293-7 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 75689.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18054 |
|---|
| Residue: | 663 |
|---|
| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
|
|
|
|---|
| BDBM50025735 |
|---|
| n/a |
|---|
| Name | BDBM50025735 |
|---|
| Synonyms: | (5Z,8Z,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid | 15-Kete | 15-Oxo-ETE | CHEMBL418941 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30O3 |
|---|
| Mol. Mass. | 318.4504 |
|---|
| SMILES | CCCCCC(=O)C=CC=CC\C=C/C\C=C/CCCC(O)=O |w:9.8,7.6| |
|---|
| Structure | 
|
|---|
Search and Browse
