| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 1D |
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| Ligand | BDBM50046575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451879 (CHEMBL3362813) |
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| IC50 | >100000±n/a nM |
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| Citation |  Cheeseman, MD; Faisal, A; Rayter, S; Barbeau, OR; Kalusa, A; Westlake, M; Burke, R; Swan, M; van Montfort, R; Linardopoulos, S; Jones, K Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg Med Chem Lett24:3469-74 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 1D |
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| Name: | Protein phosphatase 1D |
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| Synonyms: | PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66695.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515094 |
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| Residue: | 605 |
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| Sequence: | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPG
GEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHL
WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII
RGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSG
VNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHT
LDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQ
RMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK
SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAK
ALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEE
SNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRK
TVCVC
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| BDBM50046575 |
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| n/a |
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| Name | BDBM50046575 |
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| Synonyms: | CHEMBL3314467 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11FN2O2S |
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| Mol. Mass. | 326.345 |
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| SMILES | Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1 |
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| Structure | 
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