| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
|---|
| Ligand | BDBM50051104 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1448692 (CHEMBL3372050) |
|---|
| Ki | 265±n/a nM |
|---|
| Citation |  D'Ascenzio, M; Carradori, S; Secci, D; Vullo, D; Ceruso, M; Akdemir, A; Supuran, CT Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies. Bioorg Med Chem22:3982-8 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 9 |
|---|
| Name: | Carbonic anhydrase 9 |
|---|
| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49669.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 459 |
|---|
| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
|---|
| BDBM50051104 |
|---|
| n/a |
|---|
| Name | BDBM50051104 |
|---|
| Synonyms: | CHEMBL3311026 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N3O5S |
|---|
| Mol. Mass. | 405.468 |
|---|
| SMILES | CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc1cccc(c1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
