| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50053969 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1455573 (CHEMBL3364950) |
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| EC50 | 309±n/a nM |
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| Citation |  Hong, FT; Norman, MH; Ashton, KS; Bartberger, MD; Chen, J; Chmait, S; Cupples, R; Fotsch, C; Jordan, SR; Lloyd, DJ; Sivits, G; Tadesse, S; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket. J Med Chem57:5949-64 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | Gck | Gk | Glucokinase | HK IV | HK4 | HXK4_MOUSE | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52075.40 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P52792 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGE
LVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPS
VADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50053969 |
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| n/a |
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| Name | BDBM50053969 |
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| Synonyms: | CHEMBL3319561 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F6N6O4S |
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| Mol. Mass. | 616.535 |
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| SMILES | Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ncc(cc1-c1ccc2NC(=O)Cc2c1)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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