| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50056740 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1454057 (CHEMBL3361803) |
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| IC50 | 14±n/a nM |
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| Citation |  Tomoo, T; Nakatsuka, T; Katayama, T; Hayashi, Y; Fujieda, Y; Terakawa, M; Nagahira, K Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2a inhibitors. J Med Chem57:7244-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50056740 |
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| n/a |
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| Name | BDBM50056740 |
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| Synonyms: | CHEMBL3327089 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H38N2O7 |
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| Mol. Mass. | 550.6426 |
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| SMILES | NC(CO)(CO)CO.OCCOc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12 |
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| Structure | 
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