| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
|---|
| Ligand | BDBM50100958 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1452433 (CHEMBL3362457) |
|---|
| Ki | 12±n/a nM |
|---|
| Citation |  Mandapati, K; Gorla, SK; House, AL; McKenney, ES; Zhang, M; Rao, SN; Gollapalli, DR; Mann, BJ; Goldberg, JB; Cuny, GD; Glomski, IJ; Hedstrom, L Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett5:846-50 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inosine-5'-monophosphate dehydrogenase |
|---|
| Name: | Inosine-5'-monophosphate dehydrogenase |
|---|
| Synonyms: | Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43076.80 |
|---|
| Organism: | Cryptosporidium parvum |
|---|
| Description: | Q8T6T2 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAV
GMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNN
IDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIK
SKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSS
VASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYR
GMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLG
SASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
|
|
|
|---|
| BDBM50100958 |
|---|
| n/a |
|---|
| Name | BDBM50100958 |
|---|
| Synonyms: | CHEMBL3329562 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20BrN3O2 |
|---|
| Mol. Mass. | 390.274 |
|---|
| SMILES | C\C(=N/O)c1cccc(c1)C(C)(C)NC(=O)Nc1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
