| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
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| Ligand | BDBM50432765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452430 (CHEMBL3362092) |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Mandapati, K; Gorla, SK; House, AL; McKenney, ES; Zhang, M; Rao, SN; Gollapalli, DR; Mann, BJ; Goldberg, JB; Cuny, GD; Glomski, IJ; Hedstrom, L Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett5:846-50 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase |
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| Name: | Inosine-5'-monophosphate dehydrogenase |
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| Synonyms: | Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH) |
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| Type: | Protein |
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| Mol. Mass.: | 43076.80 |
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| Organism: | Cryptosporidium parvum |
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| Description: | Q8T6T2 |
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| Residue: | 400 |
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| Sequence: | MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAV
GMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNN
IDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIK
SKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSS
VASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYR
GMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLG
SASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
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| BDBM50432765 |
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| n/a |
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| Name | BDBM50432765 |
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| Synonyms: | CHEMBL2348794 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16Cl2N4O2 |
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| Mol. Mass. | 427.283 |
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| SMILES | C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| |
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| Structure | 
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