Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase 3 |
---|
Ligand | BDBM50059284 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1460602 (CHEMBL3395732) |
---|
IC50 | 288±n/a nM |
---|
Citation | Henderson, JL; Kormos, BL; Hayward, MM; Coffman, KJ; Jasti, J; Kurumbail, RG; Wager, TT; Verhoest, PR; Noell, GS; Chen, Y; Needle, E; Berger, Z; Steyn, SJ; Houle, C; Hirst, WD; Galatsis, P Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem58:419-32 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase 3 |
---|
Name: | Serine/threonine-protein kinase 3 |
Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 56284.87 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 491 |
Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
|
|
|
BDBM50059284 |
---|
n/a |
---|
Name | BDBM50059284 |
Synonyms: | CHEMBL3393445 |
Type | Small organic molecule |
Emp. Form. | C18H14N6O |
Mol. Mass. | 330.3434 |
SMILES | N#CC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |
Structure |
|