| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50061981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1462105 (CHEMBL3396812) |
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| IC50 | 1400±n/a nM |
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| Citation |  Terracciano, S; Lauro, G; Strocchia, M; Fischer, K; Werz, O; Riccio, R; Bruno, I; Bifulco, G Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors. ACS Med Chem Lett6:187-91 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM50061981 |
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| n/a |
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| Name | BDBM50061981 |
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| Synonyms: | CHEMBL3394322 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19F3N2O4 |
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| Mol. Mass. | 456.4139 |
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| SMILES | CC1=C(C(NC(=O)N1)c1ccc(o1)-c1cccc(c1)C(F)(F)F)C(=O)OCc1ccccc1 |t:1| |
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| Structure | 
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