| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50000780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1462884 (CHEMBL3399796) |
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| Ki | 0.360000±n/a nM |
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| Citation |  Schmitt, S; Colloc'h, N; Perrio, C Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies. Eur J Med Chem90:742-50 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42692.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P34975 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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|
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| BDBM50000780 |
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| n/a |
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| Name | BDBM50000780 |
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| Synonyms: | 2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide | 2-(3,4-dichlorophenyl)-N-methyl-N-[(2S)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide | CHEMBL593781 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26Cl2N2O |
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| Mol. Mass. | 369.329 |
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| SMILES | CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r| |
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| Structure | 
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