| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50066113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1465095 (CHEMBL3405427) |
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| Temperature | 298.15±n/a K |
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| IC50 | 3570±n/a nM |
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| Comments | extracted |
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| Citation |  Saxena, S; Samala, G; Renuka, J; Sridevi, JP; Yogeeswari, P; Sriram, D Development of 2-amino-5-phenylthiophene-3-carboxamide derivatives as novel inhibitors of Mycobacterium tuberculosis DNA GyrB domain. Bioorg Med Chem23:1402-12 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50066113 |
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| n/a |
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| Name | BDBM50066113 |
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| Synonyms: | CHEMBL3402954 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N2O2S |
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| Mol. Mass. | 288.365 |
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| SMILES | CCCC(=O)Nc1sc(cc1C(N)=O)-c1ccccc1 |
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| Structure | 
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