| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity choline transporter 1 |
|---|
| Ligand | BDBM87578 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1464243 (CHEMBL3404110) |
|---|
| IC50 | 4220±n/a nM |
|---|
| Citation |  Bollinger, SR; Engers, DW; Ennis, EA; Wright, J; Locuson, CW; Lindsley, CW; Blakely, RD; Hopkins, CR Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett25:1757-60 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity choline transporter 1 |
|---|
| Name: | High affinity choline transporter 1 |
|---|
| Synonyms: | CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 63194.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1464247 |
|---|
| Residue: | 580 |
|---|
| Sequence: | MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
|
|
|
|---|
| BDBM87578 |
|---|
| n/a |
|---|
| Name | BDBM87578 |
|---|
| Synonyms: | MLS001101393 | N-(2-phenylethyl)-3-(1-propylpiperidin-4-yl)oxy-benzamide | N-(2-phenylethyl)-3-(1-propylpiperidin-4-yl)oxybenzamide | N-(2-phenylethyl)-3-[(1-propyl-4-piperidinyl)oxy]benzamide | N-phenethyl-3-[(1-propyl-4-piperidyl)oxy]benzamide | SMR000664527 | cid_24819334 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H30N2O2 |
|---|
| Mol. Mass. | 366.4965 |
|---|
| SMILES | CCCN1CCC(CC1)Oc1cccc(c1)C(=O)NCCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
