Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM50068405 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1466547 (CHEMBL3407004) |
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IC50 | >20000±n/a nM |
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Citation | McElroy, WT; Michael Seganish, W; Jason Herr, R; Harding, J; Yang, J; Yet, L; Komanduri, V; Prakash, KC; Lavey, B; Tulshian, D; Greenlee, WJ; Sondey, C; Fischmann, TO; Niu, X Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4. Bioorg Med Chem Lett25:1836-41 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50068405 |
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n/a |
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Name | BDBM50068405 |
Synonyms: | CHEMBL3403430 |
Type | Small organic molecule |
Emp. Form. | C20H23N5O3S |
Mol. Mass. | 413.493 |
SMILES | Nc1nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(-c2nc3ccccc3s2)c(n1)C1CC1 |r| |
Structure |
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