| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
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| Ligand | BDBM50069505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466785 (CHEMBL3405541) |
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| IC50 | 97100±n/a nM |
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| Citation |  Vogensen, SB; Jørgensen, L; Madsen, KK; Jurik, A; Borkar, N; Rosatelli, E; Nielsen, B; Ecker, GF; Schousboe, A; Clausen, RP Structure activity relationship of selective GABA uptake inhibitors. Bioorg Med Chem23:2480-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent betaine transporter |
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| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69615.88 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460088 |
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| Residue: | 614 |
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| Sequence: | MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSS
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGR
RDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGW
LLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSP
AKQELIAWEKETHL
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| BDBM50069505 |
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| n/a |
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| Name | BDBM50069505 |
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| Synonyms: | CHEMBL3403558 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F6NO3 |
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| Mol. Mass. | 503.4772 |
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| SMILES | CN(CCOC(c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F)[C@@H]1CCCC[C@H]1C(O)=O |r| |
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| Structure | 
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