| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
|---|
| Ligand | BDBM50069385 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1466785 (CHEMBL3405541) |
|---|
| IC50 | 112202±n/a nM |
|---|
| Citation |  Vogensen, SB; Jørgensen, L; Madsen, KK; Jurik, A; Borkar, N; Rosatelli, E; Nielsen, B; Ecker, GF; Schousboe, A; Clausen, RP Structure activity relationship of selective GABA uptake inhibitors. Bioorg Med Chem23:2480-8 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent betaine transporter |
|---|
| Name: | Sodium- and chloride-dependent betaine transporter |
|---|
| Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69615.88 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1460088 |
|---|
| Residue: | 614 |
|---|
| Sequence: | MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSS
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGR
RDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGW
LLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSP
AKQELIAWEKETHL
|
|
|
|---|
| BDBM50069385 |
|---|
| n/a |
|---|
| Name | BDBM50069385 |
|---|
| Synonyms: | CHEMBL3403578 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32N2O3 |
|---|
| Mol. Mass. | 408.5332 |
|---|
| SMILES | [#6]-[#6]-[#8]-[#6](=O)-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#6@H]-1-[#7](-[#6])-[#6]-[#6]-[#8]\[#7]=[#6](/c1ccccc1)-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
