Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM50018011 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1468793 (CHEMBL3411803) |
---|
IC50 | 5012±n/a nM |
---|
Citation | Munier-Lehmann, H; Lucas-Hourani, M; Guillou, S; Helynck, O; Zanghi, G; Noel, A; Tangy, F; Vidalain, PO; Janin, YL Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). J Med Chem58:860-77 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
BDBM50018011 |
---|
n/a |
---|
Name | BDBM50018011 |
Synonyms: | Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE |
Type | Small organic molecule |
Emp. Form. | C12H9F3N2O2 |
Mol. Mass. | 270.2073 |
SMILES | C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
Structure |
|