| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Ligand | BDBM84608 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1470026 (CHEMBL3412012) |
|---|
| Kd | 15810±n/a nM |
|---|
| Citation |  Mendoza-Martínez, C; Galindo-Sevilla, N; Correa-Basurto, J; Ugalde-Saldivar, VM; Rodríguez-Delgado, RG; Hernández-Pineda, J; Padierna-Mota, C; Flores-Alamo, M; Hernández-Luis, F Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies. Eur J Med Chem92:314-31 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Synonyms: | DHFR-TS | DRTS_LEIMA | Thymidylate synthase (TS) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58691.04 |
|---|
| Organism: | Leishmania major |
|---|
| Description: | P07382 |
|---|
| Residue: | 520 |
|---|
| Sequence: | MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR
AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT
RIYATAPACTRFFPFPPENAATAWDLASSQGRRKSEAEGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVP
HAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
|
|
|
|---|
| BDBM84608 |
|---|
| n/a |
|---|
| Name | BDBM84608 |
|---|
| Synonyms: | 2,4-diamino-6-nitro-quinazoline, 1a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H7N5O2 |
|---|
| Mol. Mass. | 205.1735 |
|---|
| SMILES | Nc1nc(N)c2cc(ccc2n1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
