| Reaction Details |
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 | Report a problem with these data |
| Target | Pteridine reductase 1 |
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| Ligand | BDBM50071579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1470027 (CHEMBL3412013) |
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| Kd | 93±n/a nM |
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| Citation |  Mendoza-Martínez, C; Galindo-Sevilla, N; Correa-Basurto, J; Ugalde-Saldivar, VM; Rodríguez-Delgado, RG; Hernández-Pineda, J; Padierna-Mota, C; Flores-Alamo, M; Hernández-Luis, F Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies. Eur J Med Chem92:314-31 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pteridine reductase 1 |
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| Name: | Pteridine reductase 1 |
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| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30459.34 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_1470027 |
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| Residue: | 288 |
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| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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| BDBM50071579 |
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| n/a |
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| Name | BDBM50071579 |
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| Synonyms: | CHEMBL3410464 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2F3N7 |
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| Mol. Mass. | 456.252 |
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| SMILES | Nc1nc(N)c2cc(NCCn3c(nc4cc(Cl)c(Cl)cc34)C(F)(F)F)ccc2n1 |
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| Structure | 
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