Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM50072601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1469629 (CHEMBL3412886) |
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Ki | 0.400000±n/a nM |
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Citation | Ren, L; Grina, J; Moreno, D; Blake, JF; Gaudino, JJ; Garrey, R; Metcalf, AT; Burkard, M; Martinson, M; Rasor, K; Chen, H; Dean, B; Gould, SE; Pacheco, P; Shahidi-Latham, S; Yin, J; West, K; Wang, W; Moffat, JG; Schwarz, JB Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem58:1976-91 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50072601 |
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n/a |
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Name | BDBM50072601 |
Synonyms: | CHEMBL3409572 |
Type | Small organic molecule |
Emp. Form. | C22H23ClN4O3 |
Mol. Mass. | 426.896 |
SMILES | OCC(c1ccccc1Cl)n1ccc(cc1=O)-c1ccnc(NC2CCOCC2)n1 |
Structure |
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