| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50135141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1467842 (CHEMBL3412567) |
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| Ki | 24±n/a nM |
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| Citation |  Buron, F; Mérour, JY; Akssira, M; Guillaumet, G; Routier, S Recent advances in the chemistry and biology of pyridopyrimidines. Eur J Med Chem95:76-95 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50135141 |
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| n/a |
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| Name | BDBM50135141 |
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| Synonyms: | 6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL145979 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12Cl2N6 |
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| Mol. Mass. | 335.191 |
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| SMILES | Nc1nc(N)c2cc(CNc3cc(Cl)ccc3Cl)cnc2n1 |
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| Structure | 
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