| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM50074132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468093 (CHEMBL3413866) |
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| Ki | 300±n/a nM |
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| Citation |  Chakka, SK; Kalamuddin, M; Sundararaman, S; Wei, L; Mundra, S; Mahesh, R; Malhotra, P; Mohmmed, A; Kotra, LP Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents. Bioorg Med Chem23:2221-40 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50074132 |
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| n/a |
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| Name | BDBM50074132 |
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| Synonyms: | CHEMBL3409913 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H57N5O6 |
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| Mol. Mass. | 691.8998 |
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| SMILES | COc1ccc(OC[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCC2)cc1 |r| |
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| Structure | 
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