| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50074681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468106 (CHEMBL3413879) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Sivaprakasam, P; Han, X; Civiello, RL; Jacutin-Porte, S; Kish, K; Pokross, M; Lewis, HA; Ahmed, N; Szapiel, N; Newitt, JA; Baldwin, ET; Xiao, H; Krause, CM; Park, H; Nophsker, M; Lippy, JS; Burton, CR; Langley, DR; Macor, JE; Dubowchik, GM Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett25:1856-63 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50074681 |
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| n/a |
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| Name | BDBM50074681 |
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| Synonyms: | CHEMBL3410089 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N4O3S |
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| Mol. Mass. | 318.351 |
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| SMILES | COc1nc(sc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1 |
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| Structure | 
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