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TargetAldo-keto reductase family 1 member B10
LigandBDBM50134036
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473105 (CHEMBL3421434)
IC50 1600±n/a nM
Citation Maccari, R; Ottaną, R Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions. J Med Chem58:2047-67 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B10
Name:Aldo-keto reductase family 1 member B10
Synonyms:AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:Protein
Mol. Mass.:36024.67
Organism:Homo sapiens (Human)
Description:O60218. 1ZUA; 4JII; 4GQ0
Residue:316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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  Blast E-value cutoff:
BDBM50134036
n/a
NameBDBM50134036
Synonyms:2-(2,3-Dimethyl-phenylamino)-benzoic acid | 2-(2,3-Dimethyl-phenylamino)-benzoic acid(Mefenamic acid) | 2-(2,3-dimethylphenylamino)benzoic acid | CHEMBL686 | CI-473 | CN-35355 | INF-3355 | MEFENAMIC ACID | Ponstel | cid_4044 | mefanamic acid
TypeSmall organic molecule
Emp. Form.C15H15NO2
Mol. Mass.241.2851
SMILESCc1cccc(Nc2ccccc2C(O)=O)c1C
Structure
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