| Reaction Details |
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 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3B |
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| Ligand | BDBM50430056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473708 (CHEMBL3418014) |
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| IC50 | 7500±n/a nM |
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| Citation |  Erdmann, A; Halby, L; Fahy, J; Arimondo, PB Targeting DNA methylation with small molecules: what's next? J Med Chem58:2569-83 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA (cytosine-5)-methyltransferase 3B |
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| Name: | DNA (cytosine-5)-methyltransferase 3B |
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| Synonyms: | DNM3B_HUMAN | DNMT3B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95771.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473708 |
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| Residue: | 853 |
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| Sequence: | MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
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| BDBM50430056 |
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| n/a |
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| Name | BDBM50430056 |
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| Synonyms: | CHEMBL2336409 | SGI-1027 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N7O |
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| Mol. Mass. | 461.5178 |
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| SMILES | Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1 |
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| Structure | 
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