| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leucyl-cystinyl aminopeptidase |
|---|
| Ligand | BDBM50077103 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1473486 (CHEMBL3419982) |
|---|
| IC50 | 3300±n/a nM |
|---|
| Citation |  Papakyriakou, A; Zervoudi, E; Tsoukalidou, S; Mauvais, FX; Sfyroera, G; Mastellos, DC; van Endert, P; Theodorakis, EA; Vourloumis, D; Stratikos, E 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem58:1524-43 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leucyl-cystinyl aminopeptidase |
|---|
| Name: | Leucyl-cystinyl aminopeptidase |
|---|
| Synonyms: | Aminopeptidase | Aminopeptidase (P-LAP) | Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LCAP_HUMAN | LNPEP | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | Oxytocinase | P-LAP | Placental leucine aminopeptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 117334.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1473494 |
|---|
| Residue: | 1025 |
|---|
| Sequence: | MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
|
|
|
|---|
| BDBM50077103 |
|---|
| n/a |
|---|
| Name | BDBM50077103 |
|---|
| Synonyms: | CHEMBL3416701 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H21N3O3 |
|---|
| Mol. Mass. | 279.3348 |
|---|
| SMILES | CCCC[C@H](N)C(=O)Nc1ccc(cc1N)C(=O)OC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
