| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50077893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473395 (CHEMBL3419512) |
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| Ki | 46±n/a nM |
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| Citation |  Díaz, JL; Christmann, U; Fernández, A; Torrens, A; Port, A; Pascual, R; Álvarez, I; Burgueño, J; Monroy, X; Montero, A; Balada, A; Vela, JM; Almansa, C Synthesis and structure-activity relationship study of a new series of selectives(1) receptor ligands for the treatment of pain: 4-aminotriazoles. J Med Chem58:2441-51 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50077893 |
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| n/a |
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| Name | BDBM50077893 |
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| Synonyms: | CHEMBL3417069 | US9611229, 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19F4N5 |
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| Mol. Mass. | 357.3492 |
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| SMILES | Fc1ccc(Cn2cc(NCCN3CCC(F)(F)CC3)nn2)cc1F |
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| Structure | 
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