Ki Summary

Reaction Details

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Target

Cell division protein FtsZ

Ligand

BDBM50079359

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1470448 (CHEMBL3418982)

IC50

12300±n/a nM

Citation

Li, X; Ma, S Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ. Eur J Med Chem95:1-15 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cell division protein FtsZ

Name:

Cell division protein FtsZ

Synonyms:

FTSZ_ECOLI | ftsZ | sfiB | sulB

Type:

Protein

Mol. Mass.:

40305.83

Organism:

Escherichia coli

Description:

P0A9A6

Residue:

383

Sequence:

MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQI
GSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVA
KDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLD
AFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAA
EMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDP
DMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVND
NAPQTAKEPDYLDIPAFLRKQAD

BDBM50079359

n/a

Name

BDBM50079359

Synonyms:

Viriditoxin

Type

Small organic molecule

Emp. Form.

C34H30O14

Mol. Mass.

662.5936

SMILES

COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O |(-7.16,-4.87,;-5.83,-5.64,;-4.49,-4.86,;-4.49,-3.32,;-3.16,-5.63,;-1.82,-4.86,;-.49,-5.62,;.84,-4.86,;2.16,-5.62,;3.49,-4.86,;4.83,-5.63,;6.16,-4.85,;7.5,-5.62,;7.5,-7.16,;6.16,-3.3,;4.82,-2.54,;4.82,-1,;3.49,-3.31,;2.16,-2.55,;2.16,-1.01,;.84,-3.32,;-.49,-2.54,;-.49,-1,;-1.82,-3.32,;7.48,-2.53,;7.47,-1,;6.13,-.23,;6.12,1.31,;8.8,-.22,;10.14,-.98,;11.46,-.21,;12.8,-.96,;14.12,-.18,;15.47,-.94,;16.8,-.16,;18.14,-.93,;18.15,-2.47,;19.47,-.15,;20.81,-.91,;15.48,-2.49,;14.14,-3.27,;14.15,-4.81,;12.81,-2.51,;11.48,-3.28,;11.49,-4.82,;10.15,-2.52,;8.82,-3.3,;8.83,-4.84,)|

Structure