| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 8 |
|---|
| Ligand | BDBM50080007 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1471152 (CHEMBL3421283) |
|---|
| IC50 | 1060±n/a nM |
|---|
| Citation |  Sodji, QH; Kornacki, JR; McDonald, JF; Mrksich, M; Oyelere, AK Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids. Eur J Med Chem96:340-59 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 8 |
|---|
| Name: | Histone deacetylase 8 |
|---|
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41749.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BY41 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
|---|
| BDBM50080007 |
|---|
| n/a |
|---|
| Name | BDBM50080007 |
|---|
| Synonyms: | CHEMBL3415963 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N8O4 |
|---|
| Mol. Mass. | 454.4823 |
|---|
| SMILES | Nc1nc2ncc(CNc3ccc(cc3)C(=O)NCCCCCCC(=O)NO)nc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
